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Article

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

21 May 2021

Abstract excerpt

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs, but its role at the synapse is poorly understood. Using super-resolution imaging we determined that the localization of FUS within synapses occurs predominantly near the vesicle reserve pool of presynaptic sites. Using CLIP-seq on...

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PMID: 34021139
DOI: 10.1038/s41467-021-23188-8

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