Article
A yeast model of FUS/TLS-dependent cytotoxicity.
PLoS biology - 1 Apr 2011
Ju Shulin, Tardiff Daniel F, Han Haesun, Divya Kanneganti, Zhong Quan, Maquat Lynne E, Bosco Daryl A, Hayward Lawrence J, Brown Robert H, Lindquist Susan, Ringe Dagmar, Petsko Gregory A
Abstract excerpt
FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant forms of FUS/TLS traffic to, and form inclusions in, the cytoplasm of affected spinal motor neurons or glia. Here we report a yeast model of human FUS/TLS expression that recapitulates multiple...
Topics
- Amyotrophic Lateral Sclerosis
- Cell Nucleus
- Cytoplasm
- DNA Helicases
- Gene Expression Regulation
- Mutation
- Neurons
- RNA Helicases
- RNA, Messenger
- RNA-Binding Protein FUS
- Recombinant Fusion Proteins