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Article

A Genetic Screen for Human Genes Suppressing FUS Induced Toxicity in Yeast.

G3 (Bethesda, Md.) - 1 Jun 2020

Hayden Elliott, Chen Shuzhen, Chumley Abagail, Xia Chenyi, Zhong Quan, Ju Shulin

Abstract excerpt

FUS is a nucleic acid binding protein that, when mutated, cause a subset of familial amyotrophic lateral sclerosis (ALS). Expression of FUS in yeast recapitulates several pathological features of the disease-causing mutant proteins, including nuclear to cytoplasmic translocation, formation of cytoplasmic inclusions, and cytotoxicity. Genetic screens using the yeast model of FUS have identified yeast genes and...

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Identifiers

PMID: 32276960
DOI: 10.1534/g3.120.401164
PMCID: PMC7263679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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