Article
A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritis
2023-03-02
Abstract excerpt
Post-menopausal women present with the highest incidence and morbidity of knee osteoarthritis (KOA), but no disease-modifying therapies are available. This treatment gap may be driven by the absence of menopause in preclinical studies, as rodents do not naturally maintain a menopausal phenotype. Here, we employed a chemically-induced menopause model to map the trajectory of KOA at the tissue and proteome levels an...
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Identifiers and source
- Literature Corpus work
- cb044a60-de84-5ece-8246-e67c7a4a72d8
- DOI
- 10.1101/2023.03.02.530756