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Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in <i>Fmr1-KO</i> Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information Processing

2018-08-30

Abstract excerpt

Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). However, how developmental changes in neuronal function ultimately culminate in the network dysfunction that underlies sensory hypersensitivities is not known. To address this, we studied the layer 4 barrel cortex circuit in Fmr1 knockout mice, a critical sensory processing circuit in th...

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Literature Corpus work
a51048f2-dda1-5b04-b7bc-79c42a76697e
DOI
10.1101/403725
Open publication

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Cellular and Synaptic Phenotype Compensations Limit Circuit Disruption in <i>Fmr1-KO</i> Mouse Layer 4 Barrel Cortex but Fail to Prevent Deficits in Information ProcessingDOI 10.1101/403725
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