Article

Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X Syndrome

2022-03-15

Abstract excerpt

<h4>ABSTRACT</h4> To uncover how synaptic integration of feedforward sensory inputs is affected in autism spectrum disorders (ASD), we used two-photon uncaging of caged glutamate to activate two clustered spines in the basal dendrites of layer 5 (L5) pyramidal neurons from a mouse model of Fragile X syndrome (FXS), the most common genetic cause of ASD. While subthreshold excitatory inputs integrate linearly in wi...

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Literature Corpus work: c529136b-7484-5cb8-a644-ac0f324a7d27
DOI: 10.1101/2022.03.14.484306

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Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X SyndromeDOI 10.1101/2022.03.14.484306Read

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