Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality

Abstract excerpt

BACKGROUND: We have witnessed significant progress in gene-based approaches to cancer prognostication, promising early intervention for high-risk patients and avoidance of overtreatment for low-risk patients. However, there has been less advancement in protein-based approaches, even though perturbed protein levels and post-translational modifications are more directly linked with phenotype. Most current, gene...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Proteomics Techniques and Applications
• Share to PI3K/AKT/mTOR signaling in cancer
• Share to Prostate Cancer Treatment and Research