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Gains, Losses and Changes of Function after Gene Duplication: Study of the Metallothionein Family

25 Apr 2011

Abstract excerpt

Metallothioneins (MT) are small proteins involved in heavy metal detoxification and protection against oxidative stress and cancer. The mammalian MT family originated through a series of duplication events which generated four major genes (MT1 to MT4). MT1 and MT2 encode for ubiquitous proteins, while MT3 and MT4 evolved to accomplish specific roles in brain and epithelium, respectively. Herein, phylogenetic,...

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PMID: 21541013
DOI: 10.1371/journal.pone.0018487

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