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Article

Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2006

Safra Noa, Schaible Robert H, Bannasch Danika L

Abstract excerpt

Dalmatians, like humans, excrete uric acid in their urine. All other dogs and most mammals excrete allantoin, a water-soluble compound that is further along the purine degradation pathway. Excretion of uric acid at high concentrations (hyperuricosuria) predisposes Dalmatians to the formation of urinary urate calculi. Hyperuricosuria (huu) is found in all Dalmatians tested and is inherited as an autosomal...

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PMID: 16596455
DOI: 10.1007/s00335-005-0137-5

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