Article
Malignant hyperthermia: a pharmacogenetic disorder.
Pharmacogenomics - 1 Nov 2008
Stowell Kathryn M
Abstract excerpt
Malignant hyperthermia (MH) is a pharmacogenetic disorder triggered by volatile anesthetics or depolarizing muscle relaxants in predisposed individuals. Exercise or stress-induced MH episodes, in the absence of any obvious pharmacological trigger, have been reported, but these are rare. A considerable effort has taken place over the last two decades to identify mutations associated with MH and characterize their...
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