Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IDP-ASE: haplotyping and quantifying allele-specific expression at the gene and gene isoform level by hybrid sequencing.

Nucleic acids research - 17 Mar 2017

Deonovic Benjamin, Wang Yunhao, Weirather Jason, Wang Xiu-Jie, Au Kin Fai

Abstract excerpt

Allele-specific expression (ASE) is a fundamental problem in studying gene regulation and diploid transcriptome profiles, with two key challenges: (i) haplotyping and (ii) estimation of ASE at the gene isoform level. Existing ASE analysis methods are limited by a dependence on haplotyping from laborious experiments or extra genome/family trio data. In addition, there is a lack of methods for gene isoform level...

Topics

Join the communities discussing this publication.

Gene Expression Regulation
High-Throughput Nucleotide Sequencing
Human Embryonic Stem Cells
MCF-7 Cells
RNA Isoforms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 27899656
DOI: 10.1093/nar/gkw1076
PMCID: PMC5952581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IDP-ASE: haplotyping and quantifying allele-specific expression at the gene and gene isoform level by hybrid sequencing.PMID 27899656Read ↗

A compendium of methods: Searching allele specific expression via RNA sequencing.Semantic proximity Read ↗

aScan: A Novel Method for the Study of Allele Specific Expression in Single Individuals.Semantic proximity Read ↗

Recommendations for Accurate Resolution of Gene and Isoform Allele-Specific Expression in RNA-Seq Data.Semantic proximity Read ↗

A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes.Semantic proximity Read ↗

Revealing allele-specific gene expression by single-cell transcriptomics.Semantic proximity Read ↗

ASEP: gene-based detection of allele-specific expression in a population by RNA-seqSemantic proximity Read ↗

Highly accurate quantification of allelic gene expression for population and disease genetics.Semantic proximity Read ↗

BYASE: a Python library for estimating gene and isoform level allele-specific expression.Semantic proximity Read ↗

Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effectsSemantic proximity Read ↗

Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals.Semantic proximity Read ↗

ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing.Semantic proximity Read ↗

A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.