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Experimental evolution of <i>Pseudomonas aeruginosa</i> to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments

2023-06-12

Abstract excerpt

Antibiotic resistance is a continuing global health crisis. Identifying the evolutionary trajectories leading to increased antimicrobial resistance can be critical to the discovery of biomarkers for clinical diagnostics and new targets for drug discovery. While the combination of patient data and in vitro experimental evolution has been remarkably successful in extending our understanding of antimicrobial resista...

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Literature Corpus work
a4e26cad-d09d-583b-bffd-a64553a3bd3d
DOI
10.1101/2023.06.12.544597
Open publication

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Experimental evolution of <i>Pseudomonas aeruginosa</i> to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environmentsDOI 10.1101/2023.06.12.544597
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