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Human iPSC-RPE with the PSEN1H163R pathogenic variant recapitulates Alzheimer’s disease features and reveals melanosome defects

2025-05-12

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer’s disease (AD) is characterised by progressive cognitive decline and accumulation of pathological markers such as β-amyloid (Aβ) plaques and Tau tangles. Emerging evidence suggests these markers can also be detected in the retina, positioning it as a potential surrogate for investigating AD pathophysiology. The retinal pigment epithelium (RPE) shares features with...

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Literature Corpus work
a4cda891-8264-53a7-bb15-f002c84e2051
DOI
10.21203/rs.3.rs-6556064/v1
Open publication

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