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Article

PRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing.

Investigative ophthalmology & visual science - 5 Jan 2026

Sun Xihao, Liang Yuan, Liang Yuqin, Li Wenwei, Chen Hang, Ding Chengcheng, Duan Chunwen, Zhou Yalan, Zhang Ruting, Xu Huizhuo, Chen Jiansu

Abstract excerpt

Purpose: The pathological effects of pre-mRNA processing factor 8 (PRPF8) mutations on the retinal pigment epithelium (RPE) are not fully understood. We aimed to identify disease-specific cellular and molecular phenotypes in PRPF8 retinitis pigmentosa (RP) patient-derived induced pluripotent stem cell (iPSC)-RPE and to test whether adenine base editing (ABE), which corrects the PRPF8 mutation in iPSCs, can...

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Identifiers

PMID: 41533919
DOI: 10.1167/iovs.67.1.21
PMCID: PMC12805961

Genes

PRPF8
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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PRPF8 Mutation-Induced Defects in Human iPSC-Derived RPE Are Rescued by Adenine Base Editing.PMID 41533919Read ↗

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