Article

Single Cell Transcriptomics on PRPF31 Retinal Organoids Reveal Early Müller Glial Activation and Progressive Photoreceptor Degeneration

2025-07-02

Abstract excerpt

<title>Abstract</title> <p>Retinitis pigmentosa (RP) encompasses a group of inherited retinal disorders characterized by progressive degeneration of rod and cone photoreceptors, leading to vision loss. Among RP subtypes, RP11 is linked to mutations in PRPF31, a key spliceosome component, resulting in retinal cell dysfunction. Although PRPF31 is ubiquitously expressed, its mutations predominantly impact retinal ce...

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Literature Corpus work: 0f5c376a-fc33-5abd-a494-5a71a8d7e825
DOI: 10.21203/rs.3.rs-6923352/v1

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