Article
Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.
Nature metabolism - 1 Nov 2021
Chella Krishnan Karthickeyan, Vergnes Laurent, Acín-Pérez Rebeca, Stiles Linsey, Shum Michael, Ma Lijiang, Mouisel Etienne, Pan Calvin, Moore Timothy M, Péterfy Miklós, Romanoski Casey E, Reue Karen, Björkegren Johan L M, Laakso Markku, Liesa Marc, Lusis Aldons J
Abstract excerpt
We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex differences affect adipose mitochondrial function and metabolic syndrome are unclear. Here we show that in both mice and humans, adipose mitochondrial functions are elevated in females and are strongly associated with adiposity, insulin resistance and plasma...
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