Article
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
25 Mar 2022
Abstract excerpt
Abstract Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson’s disease are in part due to modest decrease in expression of mitochondrial complex I subunits. By contrast, diminishing expression of mitochondrial complex I genes in lower organisms increases...