Tumor Landscape Analysis: An Ecologically Informed Framework to Understand Tumor Microenvironments

Abstract excerpt

Tumor microenvironments (TMEs) are spatially complex and dynamic systems shaped by evolutionary pressures, tissue architecture, and cellular interactions. To capture this complexity, we developed the Tumor Landscape Analysis (TLA) pipeline, a computational framework applying principles from landscape ecology and spatial statistics to quantitatively characterize tumor spatial heterogeneity. TLA integrates spatially...

Topics

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• Cancer Cells and Metastasis
• Cell Image Analysis Techniques
• Clonal Evolution
• Ecosystem
• Genetic Fitness
• Genetic Heterogeneity
• Radiomics and Machine Learning in Medical Imaging
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

6f098730-10af-5d42-81bf-4af6660509b9

DOI

10.1101/2025.04.22.646608