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Article

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.

BMC cancer - 12 Aug 2016

Perimenis Philippos, Galaris Apostolos, Voulgari Alexandra, Prassa Margarita, Pintzas Alexander

Abstract excerpt

BACKGROUND: High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the cell death pathway by interfering with caspase activation. SMAC-mimetics are small-molecule inhibitors of IAPs that mimic the endogenous SMAC and promote the induction of cell death by neutralizing IAPs. METHODS: In this study, anti-tumour activity of new SMAC-mimetics...

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Identifiers

PMID: 27520705
DOI: 10.1186/s12885-016-2606-5
PMCID: PMC4982265

Genes

BRAF

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