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Article

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma.

Cell death & disease - 30 Oct 2014

McCabe K E, Bacos K, Lu D, Delaney J R, Axelrod J, Potter M D, Vamos M, Wong V, Cosford N D P, Xiang R, Stupack D G

Abstract excerpt

Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the 'inhibitor of apoptosis proteins' (IAPs), also called SMAC mimetics, as apoptosis-inducing agents whose action is opposed by caspase inhibitors. Surprisingly, IAP...

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Source

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Identifiers

PMID: 25356865
DOI: 10.1038/cddis.2014.448
PMCID: PMC4237265

Genes

RIPK3
RIPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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