Article

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicity

2023-09-14

Abstract excerpt

Adoptive T-cell therapy has become a powerful weapon for cancer treatment. The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is highly sensitive to the tumor microenvironment. It is therefore of considerable interest to bypass immunosuppressive signals in the tumor microenvironment and to identify factors that augment cytotoxic effector functions and ultimately t...

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Literature Corpus work: a41b933a-f452-5f96-a396-d30f6ca75924
DOI: 10.1101/2023.09.14.557686

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