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Article

Sodium Overload-Related Molecular Subtypes and a Four-Gene Prognostic Signature Predict Survival, Immune Landscape, and Therapeutic Response in Acute Myeloid Leukemia.

Molecular carcinogenesis - 1 Oct 2026

Wang Yuan, Yang Yi

Abstract excerpt

Sodium overload has recently emerged as a critical metabolic stressor involved in cancer progression; however, its molecular characteristics and clinical relevance in acute myeloid leukemia (AML) remain unexplored. RNA-seq data sets, clinical annotations, and mutational profiles of AML patients were annotations from The Cancer Genome Atlas and integrated with Genotype-Tissue Expression normal samples. Sodium...

Read the complete abstract on PubMed

Topics

Humans
Leukemia, Myeloid, Acute
Prognosis
Biomarkers, Tumor
Sodium
Female
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Leukemic

Nomograms

Gene Expression Profiling

Male

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 42541488
DOI: 10.1002/mc.70158
PMCID: PMC13576760

Genes

TF
ACSM1
DOCK1
GABRE
HTR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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