Article

Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients

2023-11-13

Abstract excerpt

Total proctocolectomy with ileal pouch anal anastomosis is the standard of care for patients with severe ulcerative colitis. We generated a cell-type-resolved transcriptional and epigenetic atlas of ileal pouches using scRNA-seq and scATAC-seq data from paired biopsy samples of the ileal pouch and the ileal segment above the pouch (pre-pouch) from patients (male=4, female=2), and paired biopsies of the terminal il...

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Identifiers and source

Literature Corpus work: 60172fd5-ebc0-555e-a555-39cc94b1cf5f
DOI: 10.1101/2023.11.11.23298309

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