Article

Early AMPA receptor potentiation modifies synaptic maturation and disease progression in Rett models

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in <italic>MECP2</italic> and characterized by impaired neuronal maturation and synaptic dysfunction. Positive allosteric modulators of AMPA receptors (AMPAR-PAMs) have shown therapeutic promise in RTT models, but the determinants of treatment responsiveness remain unclear. Here, we evaluated the clinica...

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Literature Corpus work: c099b5a4-3e4a-5b8d-a220-a94fb66a57c8
DOI: 10.21203/rs.3.rs-10618030/v1

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