Targeting the host transcription factor HSF1 prevents human cytomegalovirus replication in vitro and in vivo

Abstract excerpt

FDA-approved antivirals against HCMV have several limitations, including only targeting the later stages of the viral replication cycle, adverse side effects, and the emergence of drug-resistant strains. Antivirals targeting host factors specifically activated within infected cells and necessary for viral replication could address the current drawbacks of anti-HCMV standard-of-care drugs. In this study, we found H...

Topics

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• 9,10-Dimethyl-1,2-benzanthracene
• Endoplasmic Reticulum Stress and Disease
• Heat shock proteins research
• Heat Shock Transcription Factors
• Mosquito-borne diseases and control
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

0201f9ac-25d4-5511-ab07-5ded481533aa

DOI

10.1101/2024.09.23.614483