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Article

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.

Molecular cancer research : MCR - 1 Sept 2015

Nussinov Ruth, Muratcioglu Serena, Tsai Chung-Jung, Jang Hyunbum, Gursoy Attila, Keskin Ozlem

Abstract excerpt

KRAS4B is a highly oncogenic splice variant of the KRAS isoform. It is the only isoform associated with initiation of adenocarcinomas. Insight into why and how KRAS4B can mediate ductal adenocarcinomas, particularly of the pancreas, is vastly important for its therapeutics. Here we point out the overlooked critical role of calmodulin (CaM). Calmodulin selectively binds to GTP-bound K-Ras4B; but not to other Ras...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26085527
DOI: 10.1158/1541-7786.MCR-15-0165
PMCID: PMC4572916

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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