Article
α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death.
International journal of molecular sciences - 1 Jan 2023
Abuasaker Baraa, Garrido Eduardo, Vilaplana Marta, Gómez-Zepeda Jesús Daniel, Brun Sonia, Garcia-Cajide Marta, Mauvezin Caroline, Jaumot Montserrat, Pujol Maria Dolors, Rubio-Martínez Jaime, Agell Neus
Abstract excerpt
KRAS is the most frequently mutated oncogene associated with the genesis and progress of pancreatic, lung and colorectal (CRC) tumors. KRAS has always been considered as a therapeutic target in cancer but until now only two compounds that inhibit one specific KRAS mutation have been approved for clinical use. In this work, by molecular dynamics and a docking process, we describe a new compound (P14B) that stably...
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