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Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons

2024-10-16

Abstract excerpt

Most epigenetic research on post-traumatic stress disorder (PTSD) has primarily focused on DNA methylation (5mC) in peripheral tissues, particularly at CpG sites. DNA hydroxymethylation (5hmC) has been found to be highly enriched in the mammalian brain, while 5mC at non-CpG sites shows high enrichment in neurons. However, little is known about their role in PTSD. Here, we characterize genome-wide differential 5mC...

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Literature Corpus work
0eb6bb5a-8fa5-5475-bd75-5e523bd4796e
DOI
10.1101/2024.10.11.24315258
Open publication

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Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neuronsDOI 10.1101/2024.10.11.24315258
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