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Dual methylation and hydroxymethylation study of alcohol use disorder

17 Nov 2021

Abstract excerpt

Using an integrative, multi-tissue design, we sought to characterize methylation and hydroxymethylation changes in blood and brain associated with alcohol use disorder (AUD). First, we used epigenomic deconvolution to perform cell-type-specific methylome-wide association studies within subpopulations of granulocytes/T-cells/B-cells/monocytes in 1132 blood samples. Blood findings were then examined for overlap...

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PMID: 34791764
DOI: 10.1111/adb.13114

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