Article

Robust Multi-Mutant Protein Stability Prediction from a Fine-Tuned Evolutionary Scale Model

2026-06-05

Abstract excerpt

Recently, high-throughput experimental techniques have propelled improvements in deep learning-based prediction of mutation effects on protein stability. However, leading stability predictors still struggle to predict the combined effect of multiple mutations and prefer mutations that negatively impact other properties, including expressibility. To mitigate these limitations, we apply Low-Rank Adaptation (LoRA) to...

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Literature Corpus work: 182e419b-dc81-545c-af96-ae103fd73b2f
DOI: 10.64898/2026.06.04.730231

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