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Article

A Deep-Learning Sequence-Based Method to Predict Protein Stability Changes Upon Genetic Variations.

Genes - 12 Jun 2021

Pancotti Corrado, Benevenuta Silvia, Repetto Valeria, Birolo Giovanni, Capriotti Emidio, Sanavia Tiziana, Fariselli Piero

Abstract excerpt

Several studies have linked disruptions of protein stability and its normal functions to disease. Therefore, during the last few decades, many tools have been developed to predict the free energy changes upon protein residue variations. Most of these methods require both sequence and structure information to obtain reliable predictions. However, the lower number of protein structures available with respect to...

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Identifiers

PMID: 34204764
DOI: 10.3390/genes12060911
PMCID: PMC8231498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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