Article

Transfer learning to leverage larger datasets for improved prediction of protein stability changes

2023-07-30

Abstract excerpt

Amino acid mutations that lower a protein’s thermodynamic stability are implicated in numerous diseases, and engineered proteins with enhanced stability are important in research and medicine. Computational methods for predicting how mutations perturb protein stability are therefore of great interest. Despite recent advancements in protein design using deep learning, in silico prediction of stability changes has...

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Literature Corpus work: 47d07153-130d-5c53-be4b-c77031f6f0c4
DOI: 10.1101/2023.07.27.550881

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