Article
DDMut: predicting effects of mutations on protein stability using deep learning.
Nucleic acids research - 5 Jul 2023
Zhou Yunzhuo, Pan Qisheng, Pires Douglas E V, Rodrigues Carlos H M, Ascher David B
Abstract excerpt
Understanding the effects of mutations on protein stability is crucial for variant interpretation and prioritisation, protein engineering, and biotechnology. Despite significant efforts, community assessments of predictive tools have highlighted ongoing limitations, including computational time, low predictive power, and biased predictions towards destabilising mutations. To fill this gap, we developed DDMut, a...
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