Article

Lack of detectable neoantigen depletion in treatment-naïve cancers

2023-06-22

Abstract excerpt

<h4>Summary</h4> While neoantigen depletion, a form of immunoediting due to Darwinian pressure exerted by the T cell based immune system during tumor evolution, has been clearly described in murine models, its prevalence in treatment-naive, developing human tumors remains controversial. We developed two novel methodologies to test for depletion of predicted neoantigens in patient cohorts, which both compare patie...

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Literature Corpus work: 35d2ad36-d63c-50b9-bdc8-2c48576b7e56
DOI: 10.1101/2023.06.21.544805

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