Article

Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes

2025-01-24

Abstract excerpt

Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the efficiency of this process is low, partly due to the properties of somatic donor nuclei which stabilize their differentiated fate but also act as barriers reprogramming-associated cell fate changes. The identity of these...

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Literature Corpus work: dc8b806c-8031-5419-af29-18c2f7e93d03
DOI: 10.1101/2025.01.22.634227

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