Article

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

2025-11-25

Abstract excerpt

Neurons rely on glial lactate shuttling for metabolic support, which declines with aging and in neurodegenerative disease. Full disruption of lactate shuttling in peripheral nerves causes progressive axon degeneration, but we were interested to understand how partial disruption, a scenario more relevant to aging and disease, contributes to neurodegeneration risk. Pyruvate and lactate are interconverted by lactate...

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Literature Corpus work: a3c7bf64-2ca8-59b6-934e-5de20033ba60
DOI: 10.1101/2025.11.24.690227

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