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Article

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline.

PloS one - 1 Jan 2026

Tendulkar Shweta, Wu Tong, Strickland Amy, Hackett Amber R, Sato-Yamada Yurie, Mao Xianrong, Sasaki Yo, Milbrandt Jeffrey, Bloom A Joseph, DiAntonio Aaron

Abstract excerpt

Neurons rely on glial 'lactate shuttling' for metabolic support, which declines with aging and in neurodegenerative disease. Full disruption of lactate shuttling in peripheral nerves causes progressive axon degeneration, but we were interested to understand how partial disruption, a scenario more relevant to aging and disease, contributes to neurodegeneration risk. Pyruvate and lactate are interconverted by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41996350
DOI: 10.1371/journal.pone.0347135
PMCID: PMC13089715

Genes

LDHB
LDHA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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