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Article

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.

Nature neuroscience - 1 Oct 2014

Beirowski Bogdan, Babetto Elisabetta, Golden Judith P, Chen Ying-Jr, Yang Kui, Gross Richard W, Patti Gary J, Milbrandt Jeffrey

Abstract excerpt

Schwann cells (SCs) promote axonal integrity independently of myelination by poorly understood mechanisms. Current models suggest that SC metabolism is critical for this support function and that SC metabolic deficits may lead to axonal demise. The LKB1-AMP-activated protein kinase (AMPK) kinase pathway targets several downstream effectors, including mammalian target of rapamycin (mTOR), and is a key metabolic...

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Identifiers

PMID: 25195104
DOI: 10.1038/nn.3809
PMCID: PMC4494117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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