Article
High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010
Ross Jaime M, Öberg Johanna, Brené Stefan, Coppotelli Giuseppe, Terzioglu Mügen, Pernold Karin, Goiny Michel, Sitnikov Rouslan, Kehr Jan, Trifunovic Aleksandra, Larsson Nils-Göran, Hoffer Barry J, Olson Lars
Abstract excerpt
At present, there are few means to track symptomatic stages of CNS aging. Thus, although metabolic changes are implicated in mtDNA mutation-driven aging, the manifestations remain unclear. Here, we used normally aging and prematurely aging mtDNA mutator mice to establish a molecular link between mitochondrial dysfunction and abnormal metabolism in the aging process. Using proton magnetic resonance spectroscopy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.