Back to search

Article

Modelling APOL1-mediated kidney inflammation and fibrosis using a partially reprogrammed urine derived SIX2-positive renal progenitor cell line

2025-07-29

Abstract excerpt

<h4>Background</h4> CKD affects approximately 850 million people worldwide and is a leading cause of mortality. Podocytes, cells in the kidney are terminally differentiated and incapable of division in vivo making the establishment of primary cultures particularly challenging. The ability of cells to proliferate and avoid senescence is closely linked to telomere length. When telomere length becomes critically re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a3b75068-2335-546f-b0ad-ecbabd87f7df
DOI
10.1101/2025.07.28.667124
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Modelling APOL1-mediated kidney inflammation and fibrosis using a partially reprogrammed urine derived SIX2-positive renal progenitor cell lineDOI 10.1101/2025.07.28.667124
A Comprehensive Molecular Portrait of Human Urine-derived Renal Progenitor CellsSemantic proximity
Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneysSemantic proximity
JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosisSemantic proximity
Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosisSemantic proximity
The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2+ Urine Derived Renal Progenitor CellsSemantic proximity
Human Urine-derived SIX2-positive renal progenitor cells improve kidney injury in an IRI mouse modelSemantic proximity
Recapitulation of Cellular Senescence, Inflammation, and Fibrosis in Human Kidney-Derived Tubuloids by Repeated Cisplatin Treatment: A Novel Pathophysiological Model for Sensing Nephrotoxicity and Drug ScreeningSemantic proximity
Single-cell transcriptomic profiling of kidney fibrosis identifies a novel specific fibroblast marker and putative disease targetSemantic proximity
Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic StrategiesSemantic proximity
Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity
Comparative analysis of iPSC-derived human kidney organoid and tubuloid modelsSemantic proximity
Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factorsSemantic proximity
Select a neighboring publication to make it the new centre.