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Article

Modeling and Deorphanization of Orphan GPCRs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Diaz Constantino, Angelloz-Nicoud Patricia, Pihan Emilie

Abstract excerpt

Despite tremendous efforts, approximately 120 GPCRs remain orphan. Their physiological functions and their potential roles in diseases are poorly understood. Orphan GPCRs are extremely important because they may provide novel therapeutic targets for unmet medical needs. As a complement to experimental approaches, molecular modeling and virtual screening are efficient techniques to discover synthetic surrogate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29188576
DOI: 10.1007/978-1-4939-7465-8_21

Genes

GPR34
GPR52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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