Article

Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells

2023-08-10

Abstract excerpt

Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acanthocytes). VPS13A binds XK, suggesting a model in which VPS13A forms a lipid transport bridge between the ER and the plasma membrane (PM) where XK resides. However,...

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Literature Corpus work: a385107f-088f-5d7a-9c50-aca690aa8b32
DOI: 10.1101/2023.08.09.552634

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