Article

Interaction between VPS13A and the XK scramblase is required to prevent VPS13A disease in humans

2022-05-10

Abstract excerpt

VPS13 family proteins form conduits between the membranes of different organelles through which lipids are transferred. In humans there are four VPS13 paralogs each of which is required to prevent a different inherited disorder. VPS13 proteins contain multiple conserved domains. The VAB domain binds to adaptor proteins to recruit VPS13 to specific membrane contact sites. This work demonstrates the importance of a...

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Literature Corpus work: ae4d2e07-20b1-553f-a445-1a9e2ec80a57
DOI: 10.1101/2022.05.09.491223

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