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Article

Interaction between VPS13A and the XK scramblase is important for VPS13A function in humans.

Journal of cell science - 1 Sept 2022

Park Jae-Sook, Hu Yiying, Hollingsworth Nancy M, Miltenberger-Miltenyi Gabriel, Neiman Aaron M

Abstract excerpt

VPS13 family proteins form conduits between the membranes of different organelles through which lipids are transferred. In humans, there are four VPS13 paralogs, and mutations in the genes encoding each of them are associated with different inherited disorders. VPS13 proteins contain multiple conserved domains. The Vps13 adaptor-binding (VAB) domain binds to adaptor proteins that recruit VPS13 to specific...

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Identifiers

PMID: 35950506
DOI: 10.1242/jcs.260227
PMCID: PMC9482346

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