Back to search

Article

Transcription Factors DksA and PsrA are synergistic contributors to <i>L. pneumophila</i> virulence in <i>Acanthamoeba castellanii</i> protozoa

2024-07-09

Abstract excerpt

The environmental bacterium Legionella pneumophila , an intracellular parasite of free-living freshwater protozoa as well as an opportunistic human pathogen, has a biphasic lifestyle. The switch from the vegetative replicative form to the environmentally resilient transmissive phase form is governed by a complex stringent response-based regulatory network that includes RNA polymerase co-factor DksA. Here we repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a36fcf35-1362-510b-b769-bb5eff846f29
DOI
10.1101/2024.07.09.602712
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transcription Factors DksA and PsrA are synergistic contributors to <i>L. pneumophila</i> virulence in <i>Acanthamoeba castellanii</i> protozoaDOI 10.1101/2024.07.09.602712
Deep sequencing defines the transcriptional map of<i>L. pneumophila</i>and identifies growth phase-dependent regulated ncRNAs implicated in virulenceSemantic proximity
The CpxRA two-component system contributes to Legionella pneumophila virulence.Semantic proximity
More than 16,000 effectors in the <i>Legionella</i> genus genome provide multiple, independent combinations for replication in human cellsSemantic proximity
The <i>Legionella</i> autoinducer LAI-1 is delivered by outer membrane vesicles to promote inter-bacterial and inter-kingdom signalingSemantic proximity
Intrabacterial regulation of a cytotoxic effector by its cognate metaeffector promotes <i>Legionella pneumophila</i> virulenceSemantic proximity
DksA is a central regulatory switch for stress protection and virulence in Acinetobacter baumanniiSemantic proximity
DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence of <i>Klebsiella pneumoniae</i>Semantic proximity
Regulatory effects on virulence and phage susceptibility revealed by <i>sdiA</i> mutation in <i>Klebsiella pneumoniae</i>Semantic proximity
Genome dynamics in Legionella: the basis of versatility and adaptation to intracellular replication.Semantic proximity
Fine-tuning cellular levels of DprA ensures transformant fitness in the human pathogen <i>Streptococcus pneumoniae</i>Semantic proximity
Host-specific adaptation of <i>Legionella pneumophila</i> to single and multiple hostsSemantic proximity
Physiological Roles of an <i>Acinetobacter</i> -specific σ FactorSemantic proximity
Select a neighboring publication to make it the new centre.