Article

DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence of <i>Klebsiella pneumoniae</i>

2026-03-20

Abstract excerpt

Successful gastrointestinal colonization (GI) by bacterial pathogens requires adaptation to nutrient competition and host-derived stresses in the gut, with adaptation via the bacterial stringent stress response playing a critical role. Epidemiological data suggest that the GI tract serves as a reservoir from where K. pneumoniae can spread and cause invasive disease or transmit to another host. DksA is a conserved...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d392c46-0478-55ef-9df2-1312470367cb
DOI: 10.64898/2026.03.18.712580

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence of <i>Klebsiella pneumoniae</i>DOI 10.64898/2026.03.18.712580Read

Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by <i>Klebsiella pneumoniae</i>Semantic proximity Read

<i>Klebsiella pneumoniae</i> OmpR facilitates lung infection through transcriptional regulation of key virulence factorsSemantic proximity Read

Hypermucoviscosity in Klebsiella pneumoniae: manifestation, regulation, and roles in pathogenesis.Semantic proximity Read

Regulatory effects on virulence and phage susceptibility revealed by <i>sdiA</i> mutation in <i>Klebsiella pneumoniae</i>Semantic proximity Read

DksA is a central regulatory switch for stress protection and virulence in Acinetobacter baumanniiSemantic proximity Read

Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by Klebsiella pneumoniaeSemantic proximity Read

Interactions and Implications of Klebsiella pneumoniae with Human Immune Responses and Metabolic Pathways: A Comprehensive ReviewSemantic proximity Read

Transposon mutagenesis screen in <i>Klebsiella pneumoniae</i> identifies genetic determinants required for growth in human urine and serumSemantic proximity Read

The capsule regulatory network of <i>Klebsiella pneumoniae</i> defined by density-TraDISortSemantic proximity Read

Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniaeSemantic proximity Read

<i>PgaR</i> is a positive regulator of the <i>pgaABCD</i> biosynthetic operon in <i>Klebsiella pneumoniae</i>Semantic proximity Read

The small protein RmpD drives hypermucoviscosity in <i>Klebsiella pneumoniae</i>Semantic proximity Read