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In silico phosphoproteomic analysis reveals divergent regulation of Presenilin 1 and Presenilin 2

2025-09-04

Abstract excerpt

The Presenilins are multi-pass transmembrane proteins that form part of the multi-protein gamma secretase complex. The hydrolytic activity of the gamma secretase complex is responsible for the cleavage of a wide range of substrates, including the amyloid precursor protein (APP) – a proteolytic event that is the final step in the production of the amyloid beta peptide, a protein fragment deposited in the brains of...

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Literature Corpus work
a35f840e-60df-559a-8d25-f1930d9e9fbb
DOI
10.22541/au.175700731.13994315/v1
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In silico phosphoproteomic analysis reveals divergent regulation of Presenilin 1 and Presenilin 2DOI 10.22541/au.175700731.13994315/v1
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