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Article

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.

International immunopharmacology - 1 Dec 2002

Wolfe Michael S

Abstract excerpt

Deposition of the amyloid-beta protein (Abeta) in the form of cerebral plaques is a defining pathological feature of Alzheimer's disease (AD), and all AD-causing genes identified to date affect Abeta production or deposition. For these reasons, the two proteases, beta- and gamma-secretases, that cut out Abeta from the amyloid-beta precursor protein (APP) are considered important targets for the development of...

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Source

Identifiers

PMID: 12489805
DOI: 10.1016/s1567-5769(02)00179-0

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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