Article

Retinal BMI1 Expression Preserves Photoreceptors in Sodium Iodate-Induced Oxidative Stress Models

2025-04-21

Abstract excerpt

Dry age-related macular degeneration (AMD) is a leading cause of blindness in people over 50 with limited therapeutic options. The sodium iodate (NaIO3)-induced retinal degeneration model mimics oxidative stress-induced cell death in dry AMD. BMI1, a polycomb ring finger protein involved in DNA repair and cell renewal, is a potential therapeutic target for oxidative retinal injury. We evaluated the efficacy of AAV...

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Literature Corpus work: 63279f61-257f-574f-86b2-70ec659db191
DOI: 10.20944/preprints202504.1758.v1

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