Article

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

2025-09-01

Abstract excerpt

<h4>SUMMARY</h4> Oct4, Sox2, and Klf4 (OSK) Yamanaka factors induce pluripotency and reverse age-related epigenetic changes, yet the mechanisms by which they promote rejuvenation remain poorly explored. Oxidative stress contributes to CNS aging and retinal pigmented epithelium (RPE) degeneration in age-related macular degeneration. We find that OSK expression in RPE restores retinal structure and visual function...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59836c04-2b0e-5dc5-a222-bde180266cfc
DOI: 10.1101/2025.08.30.673239

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore VisionDOI 10.1101/2025.08.30.673239Read

Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identitySemantic proximity Read

Comparative single-cell multiomic analysis reveals evolutionarily conserved and species-specific cellular mechanisms mediating natural retinal agingSemantic proximity Read

Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenationSemantic proximity Read

Translatomic response of retinal Müller glia to acute and chronic stressSemantic proximity Read

A single factor for safer cellular rejuvenationSemantic proximity Read

Epigenetic Mechanisms of the Aging Human RetinaSemantic proximity Read

Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)Semantic proximity Read

Senescence targeting re-enables injury-responsive repair in a human RPE aging modelSemantic proximity Read

AAV NRF2 Gene Therapy Preserves Retinal Structure and Function in Rodent Models of Oxidative DamageSemantic proximity Read

Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration.Semantic proximity Read

Machine Learning Ensemble Reveals Distinct Molecular Pathways of Retinal Damage in Spaceflown MiceSemantic proximity Read

Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of GlaucomaSemantic proximity Read